Investigation of the impact of grapefruit juice, pomegranate juice and tomato juice on pharmacokinetics of brexpiprazole in rats using UHPLC-QTOF-MS.

Thakkar, Disha; Sahu, Amit Kumar; Rathod, Rajeshwari; Sengupta, Pinaki; Kate, Abhijeet S

Thakkar, Disha; Sahu, Amit Kumar; Rathod, Rajeshwari; Sengupta, Pinaki; Kate, Abhijeet S.

Afiliação

Thakkar D; Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad, An Institute of National Importance, Government of India, Gandhinagar, Gujarat, India.
Sahu AK; Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad, An Institute of National Importance, Government of India, Gandhinagar, Gujarat, India.
Rathod R; Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad, An Institute of National Importance, Government of India, Gandhinagar, Gujarat, India.
Sengupta P; Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad, An Institute of National Importance, Government of India, Gandhinagar, Gujarat, India.
Kate AS; Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, National Institute of Pharmaceutical Education and Research-Ahmedabad, An Institute of National Importance, Government of India, Gandhinagar, Gujarat, India.

Biomed Chromatogr ; 35(11): e5201, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34148241

Assuntos

Cromatografia Líquida de Alta Pressão/métodos; Sucos de Frutas e Vegetais; Espectrometria de Massas/métodos; Quinolonas; Tiofenos; Animais; Citrus paradisi/química; Interações Ervas-Drogas; Limite de Detecção; Modelos Lineares; Solanum lycopersicum/química; Masculino; Punica granatum/química; Quinolonas/análise; Quinolonas/farmacocinética; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Tiofenos/análise; Tiofenos/farmacocinética

Palavras-chave

brexpiprazole; fruit juice-drug interaction; fruit juices; pharmacokinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Tiofenos / Cromatografia Líquida de Alta Pressão / Quinolonas / Sucos de Frutas e Vegetais Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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