Alternative polyadenylation-associated loci interpret human traits and diseases.

Fang, Zhixiao; Li, Shengli

Fang, Zhixiao; Li, Shengli.

Afiliação

Fang Z; Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.
Li S; Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: shengli.li@shsmu.edu.cn.

Trends Genet ; 37(9): 773-775, 2021 09.

Article em En | MEDLINE | ID: mdl-34148698

ABSTRACT

ABSTRACT

Alternative polyadenylation (APA)-associated genetic variants have been proposed to impact diverse human phenotypes and disorders. In a recent study, Li et al. established a landscape of 3'-untranslated region (UTR) APA quantitative trait loci (3'aQTLs) across multiple human tissues, revealing substantial 3'aQTLs that contribute to complex human traits and diseases.

Assuntos

Poliadenilação; Locos de Características Quantitativas; Regiões 3' não Traduzidas; Humanos; Herança Multifatorial; Fenótipo

Palavras-chave

alternative polyadenylation; complex traits; human diseases; quantitative trait loci

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliadenilação / Locos de Características Quantitativas Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google