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Glioma Associated Microglia/Macrophages Distribution is Conserved in Glioblastoma Regrowth: A Morphometric Study.
Pautrat, Arnaud; Vassal, François; Casteillo, François; Magné, Nicolas; Péoc'h, Michel; Forest, Fabien.
Afiliação
  • Pautrat A; Department of Pathology, University Jean Monnet, Saint Etienne, France.
  • Vassal F; Department of Neurosurgery, University Jean Monnet, Saint Etienne, France.
  • Casteillo F; Department of Pathology, University Jean Monnet, Saint Etienne, France.
  • Magné N; Department of Radiotherapy, University Jean Monnet, Saint Etienne, France.
  • Péoc'h M; Department of Pathology, University Jean Monnet, Saint Etienne, France.
  • Forest F; Department of Pathology, University Jean Monnet, Saint Etienne, France.
Cancer Invest ; 39(8): 621-626, 2021 Sep.
Article em En | MEDLINE | ID: mdl-34151673
We compared the morphological aspect of glioblastoma-associated microglia/macrophages cells in 15 paired recurrent glioblastomas to check the ability of glioblastoma to recreate its microenvironment. The absolute number of GAMs is lower in normal tissue (21/mm2) than in the isolated tumor cells area (100-112/mm2) than in the solid tumor area (212-220/mm2) (p < 0.01). The morphology of GAMs remained the same in each tumor area with a reduced covered area by cell processes (196 to 216/mm2) than in normal tissue (708/mm2) (p < 0.01). In paired tumors, GAMs morphology remained the same in successive resections and was not modified by the treatments.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microglia / Glioblastoma / Glioma / Macrófagos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microglia / Glioblastoma / Glioma / Macrófagos Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article