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Chemical Constituents from Staminate Flowers of Eucommia ulmoides Oliver and Their Anti-Inflammation Activity in Vitro.
Li, Rui; Huang, Tao; Nie, Lanlan; Jia, An; Zhang, Lei; Yuan, Ying; Hong, Yanlong; Wang, Jianying; Hu, Xiao.
Afiliação
  • Li R; Shanghai Innovation Center of Health Service, Shanghai University of Traditional Chinese Medicine, No. 1220, Cailun Rd., Shanghai, 201203, P. R. China.
  • Huang T; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai, 201203, P. R. China.
  • Nie L; Medical School, Huanghe Science and Technology College, Zhengzhou, 450000, P. R. China.
  • Jia A; Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai, 201203, P. R. China.
  • Zhang L; Medical School, Huanghe Science and Technology College, Zhengzhou, 450000, P. R. China.
  • Yuan Y; Shanghai Innovation Center of Health Service, Shanghai University of Traditional Chinese Medicine, No. 1220, Cailun Rd., Shanghai, 201203, P. R. China.
  • Hong Y; Shanghai Innovation Center of Health Service, Shanghai University of Traditional Chinese Medicine, No. 1220, Cailun Rd., Shanghai, 201203, P. R. China.
  • Wang J; Shanghai Innovation Center of Health Service, Shanghai University of Traditional Chinese Medicine, No. 1220, Cailun Rd., Shanghai, 201203, P. R. China.
  • Hu X; Shanghai Innovation Center of Health Service, Shanghai University of Traditional Chinese Medicine, No. 1220, Cailun Rd., Shanghai, 201203, P. R. China.
Chem Biodivers ; 18(8): e2100331, 2021 Aug.
Article em En | MEDLINE | ID: mdl-34155779
ABSTRACT
Three new monoterpenoids, named eucomylides A-C (1-3), along with six known compounds (4-9) were isolated from the staminate flowers of Eucommia ulmoides Oliver. The structures were elucidated by extensive analyses of spectroscopic methods, and their absolute configurations were established by time-dependent density functional theory electronic circular dichroism (TDDFT ECD) calculation. All the compounds along with previously isolated components (10-14) were tested for their anti-inflammatory effects. Two iridoid glycosides (11 and 12) and a flavonoid glycoside (14) showed potent suppressive effects on nitric oxide (NO) production in RAW 264.7 cells, with IC50 values ranging from 17.11 to 22.26 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eucommiaceae / Monoterpenos / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Eucommiaceae / Monoterpenos / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article