Two new sphingolipids from the stem bark of Synsepalum msolo (Sapotaceae).

ABSTRACT

Synsepalum msolo commonly known as Bang Bali in Bali-Nguemba, Cameroon is used in traditional medicine against various diseases. The leaves and stem bark extracts were subjected to silica gel and Sephadex LH20 column chromatography to yield pure compounds. The structures of the compounds were determined by detail analysis of NMR and Mass spectroscopic data and by comparison with data reported in the literature. Amongst the isolates, were two new sphingolipids synsepaloside B (1), synsepaloside C (2), and five known compounds (+)-catechin (3), (-)-epicatechin (4), myricitrin (5), triacontanol (6), and aurantiamide acetate (7). Compounds 1-5 were screened for their antibacterial and anti-yeast activities on several microorganisms. All the tested compounds exhibited weak antibacterial (MIC ≥ 200 µg/mL) and anti-yeast (MIC > 200 µg/mL) activities as compared to standard ciprofloxacin 0.468 < MIC >0.234 µg/mL and fluconazole MIC = 0.05 µg/mL, respectively.