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Quality of life in adults with acute lymphoblastic leukemia in France: results from a French cross-sectional study.
Lepretre, Stephane; Touboul, Chantal; Flinois, Alain; Kutikova, Lucie; Giannopoulou, Christina; Makhloufi, Kahina; Chauny, Jean-Vannak; Désaméricq, Gaëlle.
Afiliação
  • Lepretre S; Hematology Clinic, Centre Henri Becquerel, Rouen, France.
  • Touboul C; Real World Evidence, Epidemiology and Observational Research, Kantar Health, Paris, France.
  • Flinois A; Department of Oncology, Kantar Health, Paris, France.
  • Kutikova L; Amgen (Europe) GmbH, Rotkreuz, Switzerland.
  • Giannopoulou C; Amgen (Europe) GmbH, Rotkreuz, Switzerland.
  • Makhloufi K; Amgen France, Boulogne-Billancourt, France.
  • Chauny JV; Amgen France, Boulogne-Billancourt, France.
  • Désaméricq G; Amgen France, Boulogne-Billancourt, France.
Leuk Lymphoma ; 62(12): 2957-2967, 2021 12.
Article em En | MEDLINE | ID: mdl-34162314
In recent years, treatment of acute lymphoblastic leukemia (ALL) has improved substantially, leading to longer survival. This has necessitated a greater focus on health-related quality of life (HRQoL), but data are lacking. In a part-prospective, part-retrospective study, we enrolled 219 adults with ALL in France to assess the impact of key disease and treatment characteristics on HRQoL. Overall HRQoL and most specific QoL domain scores were consistently better among patients receiving front-line therapy, those currently in complete remission, and those who had previously received hematopoietic stem-cell transplantation. Furthermore, HRQoL was consistently impaired in patients with minimal residual disease present (MRD+). In multivariate analyses, multiple lines of therapy, MRD+, leukopenia, comorbidities, and anemia were significantly associated with impaired HRQoL. This study provides real-world data on HRQoL in adults with ALL in France and shows the positive impact of MRD-negative status on HRQoL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article