Epigenetics and sarcoidosis.
Eur Respir Rev
; 30(160)2021 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-34168064
ABSTRACT
Epigenetic modifications are emerging as important regulatory mechanisms of gene expression in lung disease, given that they are influenced by environmental exposures and genetic variants, and that they regulate immune and fibrotic processes. In this review, we introduce these concepts with a focus on the study of DNA methylation and histone modifications and discuss how they have been applied to lung disease, and how they can be applied to sarcoidosis. This information has implications for other exposure and immunologically mediated lung diseases, such as chronic beryllium disease, hypersensitivity pneumonitis, and asbestosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sarcoidose
/
Pneumopatias
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article