Huntington's disease: nearly four decades of human molecular genetics.
Hum Mol Genet
; 30(R2): R254-R263, 2021 10 01.
Article
em En
| MEDLINE
| ID: mdl-34169318
ABSTRACT
Huntington's disease (HD) is a devastating neurogenetic disorder whose familial nature and progressive course were first described in the 19th century but for which no disease-modifying treatment is yet available. Through the active participation of HD families, this disorder has acted as a flagship for the application of human molecular genetic strategies to identify disease genes, understand pathogenesis and identify rational targets for development of therapies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Huntington
/
Suscetibilidade a Doenças
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article