Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.

Herman, Allison B; Anerillas, Carlos; Harris, Sophia C; Munk, Rachel; Martindale, Jennifer L; Yang, Xiaoling; Mazan-Mamczarz, Krystyna; Zhang, Yongqing; Heckenbach, Indra J; Scheibye-Knudsen, Morten; De, Supriyo; Sen, Payel; Abdelmohsen, Kotb; Gorospe, Myriam

Herman, Allison B; Anerillas, Carlos; Harris, Sophia C; Munk, Rachel; Martindale, Jennifer L; Yang, Xiaoling; Mazan-Mamczarz, Krystyna; Zhang, Yongqing; Heckenbach, Indra J; Scheibye-Knudsen, Morten; De, Supriyo; Sen, Payel; Abdelmohsen, Kotb; Gorospe, Myriam.

Afiliação

Herman AB; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Anerillas C; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Harris SC; Confocal Imaging Facility, Laboratory of Cardiovascular Sciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Munk R; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Martindale JL; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Yang X; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Mazan-Mamczarz K; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Zhang Y; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Heckenbach IJ; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, DK-2200, Denmark.
Scheibye-Knudsen M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, DK-2200, Denmark.
De S; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Sen P; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Abdelmohsen K; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.
Gorospe M; Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD 21224, USA.

Nucleic Acids Res ; 49(13): 7389-7405, 2021 07 21.

Article em En | MEDLINE | ID: mdl-34181735

Assuntos

Senescência Celular/genética; MicroRNAs/metabolismo; Receptores Citoplasmáticos e Nucleares/genética; Linhagem Celular; Proliferação de Células; Células Cultivadas; Senescência Celular/efeitos dos fármacos; Regulação da Expressão Gênica; Heterocromatina; Humanos; Receptores Citoplasmáticos e Nucleares/metabolismo; Receptor de Lamina B

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Senescência Celular / Receptores Citoplasmáticos e Nucleares / MicroRNAs Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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