In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.

Pokorny, Daniel; Truebestein, Linda; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A

In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate.

Pokorny, Daniel; Truebestein, Linda; Fleming, Kaelin D; Burke, John E; Leonard, Thomas A.

Afiliação

Pokorny D; Department of Structural and Computational Biology, Max Perutz Labs, Vienna, Austria; Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria.
Truebestein L; Department of Structural and Computational Biology, Max Perutz Labs, Vienna, Austria; Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria.
Fleming KD; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.
Burke JE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.
Leonard TA; Department of Structural and Computational Biology, Max Perutz Labs, Vienna, Austria; Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria. Electronic address: thomas.leonard@meduniwien.ac.at.

J Biol Chem ; 297(2): 100919, 2021 08.

Article em En | MEDLINE | ID: mdl-34181950

Assuntos

Classe I de Fosfatidilinositol 3-Quinases/metabolismo; Endossomos/metabolismo; Lipossomos/química; Neoplasias/patologia; Fosfatos de Fosfatidilinositol/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Classe III de Fosfatidilinositol 3-Quinases/metabolismo; Humanos; Técnicas In Vitro; Lipossomos/metabolismo; Espectrometria de Massas/métodos; Neoplasias/enzimologia; Fosfatos de Fosfatidilinositol/química; Proteínas Serina-Treonina Quinases/química; Elementos Estruturais de Proteínas; Transdução de Sinais

Palavras-chave

CISK; Sgk3; allosteric regulation; endosome; hydrogendeuterium exchange mass spectrometry (HDX-MS); phosphatidylinositide 3-kinase (PI 3-kinase); phospholipid; serine/threonine protein kinase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endossomos / Proteínas Serina-Treonina Quinases / Fosfatos de Fosfatidilinositol / Classe I de Fosfatidilinositol 3-Quinases / Lipossomos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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