IgA potentiates NETosis in response to viral infection.
Proc Natl Acad Sci U S A
; 118(27)2021 07 06.
Article
em En
| MEDLINE
| ID: mdl-34183391
ABSTRACT
IgA is the second most abundant antibody present in circulation and is enriched at mucosal surfaces. As such, IgA plays a key role in protection against a variety of mucosal pathogens including viruses. In addition to neutralizing viruses directly, IgA can also stimulate Fc-dependent effector functions via engagement of Fc alpha receptors (Fc-αRI) expressed on the surface of certain immune effector cells. Neutrophils are the most abundant leukocyte, express Fc-αRI, and are often the first to respond to sites of injury and infection. Here, we describe a function for IgA-virus immune complexes (ICs) during viral infections. We show that IgA-virus ICs potentiate NETosis-the programmed cell-death pathway through which neutrophils release neutrophil extracellular traps (NETs). Mechanistically, IgA-virus ICs potentiated a suicidal NETosis pathway via engagement of Fc-αRI on neutrophils through a toll-like receptor-independent, NADPH oxidase complex-dependent pathway. NETs also were capable of trapping and inactivating viruses, consistent with an antiviral function.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Viroses
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Imunoglobulina A
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Armadilhas Extracelulares
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Neutrófilos
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article