Gene-Environment Interactions Between Environmental Response Genes Polymorphisms and Mitochondrial DNA Copy Numbers Among Benzene Workers.
J Occup Environ Med
; 63(7): e408-e415, 2021 07 01.
Article
em En
| MEDLINE
| ID: mdl-34184658
ABSTRACT
OBJECTIVE:
To determine the effect of mitochondrial DNA copy number (mtDNAcn) as a biomarker of benzene exposure.METHODS:
A total of 294 benzene-exposed workers and 102 controls were recruited. Biomarkers of mtDNAcn, cytokinesis-block micronucleus (MN) frequency, and peripheral blood white blood cells (WBC) were detected. Eighteen polymorphism sites in DNA damage repair and metabolic genes were analyzed.RESULTS:
Benzene exposure increased mtDNAcn and indicated a dose-response relationship (Pâ<â0.001). mtDNAcn was negatively correlated with WBC count and DNA methylation and positively correlated with MN frequency. The AG type in rs1695 interacted with benzene exposure to aggravate mtDNAcn (ßâ=â0.006, 95% CI 0, 0.012, Pâ=â0.050). rs13181, rs1695, rs1800975, and GSTM1 null were associated with benzene-induced mtDNAcn. Rs1695 interacted with benzene to increase mitochondrial damage.CONCLUSIONS:
Benzene exposure increases mtDNAcn levels in benzene-exposed workers.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzeno
/
Exposição Ocupacional
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article