The Microenvironment of Tongue Cancer.
Adv Exp Med Biol
; 1296: 49-78, 2020.
Article
em En
| MEDLINE
| ID: mdl-34185286
ABSTRACT
Cancer cells interact with and remodel the surrounding microenvironment. An increasing number of studies focus on tongue tumor microenvironment (TME) to find novel approaches to investigate tongue cancer, indicating that tongue tumor microenvironment is recognized as a critical element for tongue tumor development and metastasis and as a potential therapeutic target. In this paper, we review the extrinsic features of the tongue tumor microenvironment, including its various components, and the intrinsic characteristics of TME, including heterogeneity, cell death, and metastatic potential. We also report on the cross talk between these intrinsic and extrinsic components. We believe that the exploration of the tongue tumor microenvironment can provide guidance for the treatments and improve the overall survival and quality of patients' lives.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Língua
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article