Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide.
Neuron
; 109(15): 2469-2484.e7, 2021 08 04.
Article
em En
| MEDLINE
| ID: mdl-34186026
ABSTRACT
The olfactory system serves a critical function as a danger detection system to trigger defense responses essential for survival. The cellular and molecular mechanisms that drive such defenses in mammals are incompletely understood. Here, we have discovered an ultrasensitive olfactory sensor for the highly poisonous bacterial metabolite hydrogen sulfide (H2S) in mice. An atypical class of sensory neurons in the main olfactory epithelium, the type B cells, is activated by both H2S and low O2. These two stimuli trigger, respectively, Cnga2- and Trpc2-signaling pathways, which operate in separate subcellular compartments, the cilia and the dendritic knob. This activation drives essential defensive responses elevation of the stress hormone ACTH, stress-related self-grooming behavior, and conditioned place avoidance. Our findings identify a previously unknown signaling paradigm in mammalian olfaction and define type B cells as chemosensory neurons that integrate distinct danger inputs from the external environment with appropriate defense outputs.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Olfato
/
Mucosa Olfatória
/
Neurônios Receptores Olfatórios
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Reação de Fuga
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article