Mechanism of mitotic recombination: insights from C. elegans.
Curr Opin Genet Dev
; 71: 10-18, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34186335
ABSTRACT
Homologous recombination (HR) plays a critical role in largely error-free repair of mitotic and meiotic DNA double-strand breaks (DSBs). DSBs are one of the most deleterious DNA lesions, which are repaired by non-homologous end joining (NHEJ), homologous recombination (HR) or, if compromised, micro-homology mediated end joining (MMEJ). If left unrepaired, DSBs can lead to cell death or if repaired incorrectly can result in chromosome rearrangements that drive cancer development. Here, we describe recent advances in the field of mitotic HR made using Caenorhabditis elegans roundworm, as a model system.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Caenorhabditis elegans
/
Reparo do DNA por Junção de Extremidades
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article