Use of hypertonic glucose (10%) in the prevention of postoperative adhesions in rats.
Acta Cir Bras
; 36(5): e360504, 2021.
Article
em En
| MEDLINE
| ID: mdl-34190774
ABSTRACT
PURPOSE:
To evaluate the efficacy of hypertonic glucose (10%), alone or in combination with the corticoid dexamethasone, to prevent peritoneal adhesion following hysterectomy in rats.METHODS:
Forty-two adult rats underwent hysterectomy with peritoneal lavage G1 - glucose (10%); G2 - glucose (10%) and dexamethasone 3 mg·kg-1; and G3 - physiological saline (PS) 0.9%.RESULTS:
In the macroscopic analysis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001), G3 compared to G1 and G2. There was no difference between groups after 28 days. In the microscopic analysis, the median vascular proliferation after 14 days was 2 for G1, 1 for G2, and 3 for G3 (p = 0.0037, G3 vs. G1 and G2). After 28 days, G1 showed a median vascular proliferation score of 2, G2 of 2.5, and G3 of 3 (p < 0.0001, G3 vs. G1 and G2). Regarding the inflammatory reaction after 14 days, G1 had a median score of 2, G2 of 1, and G3 of 3 (p = 0.7916). After 28 days, G1 had a median score of 0.5 (0-1.75), G2 of 1.5, and G3 of 2.5 (p < 0.0001, G3 vs. the others and G2 vs. G1). In the evaluation of fibrosis after 14 days, G1 had a median score of 1, G2 of 1, and G3 of 2.5 (p < 0.0001, G3 vs. G1and G2). After 28 days, G1 had a median fibrosis score of 1, G2 2, and G3 2.5 (p < 0.0001), G3 vs. the others andG2 vs. G1).CONCLUSIONS:
The use of hypertonic glucose (10%) solution seems to reduce macroscopic and microscopic pelvic adhesions.
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Base de dados:
MEDLINE
Assunto principal:
Glucose
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article