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Critical Review of the Evolution of Extracellular Vesicles' Knowledge: From 1946 to Today.
Bazzan, Erica; Tinè, Mariaenrica; Casara, Alvise; Biondini, Davide; Semenzato, Umberto; Cocconcelli, Elisabetta; Balestro, Elisabetta; Damin, Marco; Radu, Claudia Maria; Turato, Graziella; Baraldo, Simonetta; Simioni, Paolo; Spagnolo, Paolo; Saetta, Marina; Cosio, Manuel G.
Afiliação
  • Bazzan E; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Tinè M; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Casara A; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Biondini D; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Semenzato U; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Cocconcelli E; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Balestro E; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Damin M; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Radu CM; Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.
  • Turato G; Department of Medicine, University of Padova, 35128 Padova, Italy.
  • Baraldo S; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Simioni P; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Spagnolo P; Department of Medicine, University of Padova, 35128 Padova, Italy.
  • Saetta M; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
  • Cosio MG; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.
Int J Mol Sci ; 22(12)2021 Jun 15.
Article em En | MEDLINE | ID: mdl-34203956
ABSTRACT
Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and promotion of repair. Their existence, initially suspected in 1946 and confirmed in 1967, spurred a sharp increase in the number of scientific publications. Paradoxically, the increasing interest for EV content and function progressively reduced the relevance for a precise nomenclature in classifying EVs, therefore leading to a confusing scientific production. The aim of this review was to analyze the evolution of the progress in the knowledge and definition of EVs over the years, with an overview of the methodologies used for the identification of the vesicles, their cell of origin, and the detection of their cargo. The MISEV 2018 guidelines for the proper recognition nomenclature and ways to study EVs are summarized. The review finishes with a "more questions than answers" chapter, in which some of the problems we still face to fully understand the EV function and potential as a diagnostic and therapeutic tool are analyzed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares Tipo de estudo: Guideline / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares Tipo de estudo: Guideline / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article