Concise Synthesis of Both Enantiomers of Pilocarpine.
Molecules
; 26(12)2021 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-34208623
ABSTRACT
Furan-2-carboxylic acid was used as a starting material for the synthesis of dehydro-homopilopic acid. Esterification, hydrogenation and enzymatic hydrolysis followed by the reduction of Weinreb amides and a single-step attachment of a 1-methyl-imidazole residue allowed for the concise synthesis of both enantiomers of pilocarpine.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pilocarpina
/
4-Butirolactona
/
Furanos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article