Evidence of bacterial DNA presence in chorionic villi and amniotic fluid in the first and second trimester of pregnancy.
Future Microbiol
; 16: 801-810, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-34223788
ABSTRACT
The sterile-womb dogma in uncomplicated pregnancy has been lively debated. Data regarding the in utero microbiome environment are based mainly on studies performed at the time of delivery. Aim:
To determine whether human placenta and amniotic fluid are populated by a bacterial microbiota in the first and second trimesters of pregnancy. Materials &methods:
We analyzed by next-generation sequencing method 24 and 29 samples from chorionic villus sampling (CVS) and amniocentesis (AC), respectively. The V3 region of the 16S rRNA gene was sequenced.Results:
37.5% of CVS and 14% of AC samples showed the presence of bacterial DNA.Conclusion:
Our study suggests that bacterial DNA can be identified in the placenta and amniotic fluid during early prenatal life.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA Bacteriano
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Vilosidades Coriônicas
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Microbiota
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Líquido Amniótico
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article