T cell asymmetry and metabolic crosstalk can fine-tune immunological synapses.
Trends Immunol
; 42(8): 649-653, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34226146
ABSTRACT
T cell asymmetry upon specific cell-cell interactions during mammalian immunological synapse (IS) contacts requires mammalian target of rapamycin complex (mTORC) activation and chaperones, such as the eukaryotic chaperonin containing TCP1 (CCT) for protein synthesis and folding. This mechanism can control cytoskeleton dynamics, and regulate mitochondrial fate, respiration, and metabolic rates, ultimately underlying cell reprogramming events that are relevant for CD4+ T cell functional outcomes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Sinapses Imunológicas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article