Visible light-induced one-pot synthesis of CF3/CF2-substituted cyclobutene derivatives.
Chem Commun (Camb)
; 57(60): 7441-7444, 2021 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-34232233
ABSTRACT
An efficient one-pot approach for the controllable synthesis of trifluoromethyl/gem-difluoromethylene substituted cyclobutene derivatives has been developed. The mechanism may involve visible light-induced [2+2]-cycloaddition of quinolinones with 1-bromo-1-trifluoromethylethene, followed by base-promoted dehydrobromination, [1,3]-H shift and further dehydrofluorination. A variety of CF3/CF2-substituted cyclobutenes that are currently difficult to obtain are afforded in good yields in this protocol, which may find its way into future fluorinated cyclobutene preparation.
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MEDLINE
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En
Ano de publicação:
2021
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Article