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TP53-mediated therapy-related clonal hematopoiesis contributes to doxorubicin-induced cardiomyopathy by augmenting a neutrophil-mediated cytotoxic response.
Sano, Soichi; Wang, Ying; Ogawa, Hayato; Horitani, Keita; Sano, Miho; Polizio, Ariel H; Kour, Anupreet; Yura, Yoshimitsu; Doviak, Heather; Walsh, Kenneth.
Afiliação
  • Sano S; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Wang Y; Department of Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Ogawa H; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Horitani K; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Sano M; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Polizio AH; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Kour A; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Yura Y; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Doviak H; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Walsh K; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
JCI Insight ; 6(13)2021 07 08.
Article em En | MEDLINE | ID: mdl-34236050
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Doxorrubicina / Proteína Supressora de Tumor p53 / Infiltração de Neutrófilos / Cardiotoxicidade / Hematopoiese Clonal Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Doxorrubicina / Proteína Supressora de Tumor p53 / Infiltração de Neutrófilos / Cardiotoxicidade / Hematopoiese Clonal Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article