Case Report: Refractory Cryptosporidiosis after CAR T-Cell Therapy for Lymphoma.
Am J Trop Med Hyg
; 105(3): 651-653, 2021 07 08.
Article
em En
| MEDLINE
| ID: mdl-34237021
ABSTRACT
Cryptosporidial diarrhea is uncommon in immunocompetent individuals, more often seen in severely immunocompromised patients. Severe refractory cases have been described in patients with HIV/AIDS before the advent of modern antiretroviral therapy due to an inability to mount an adequate cellular immune response. We describe an 85-year-old patient post-chimeric antigen receptor T-cell therapy relapsed lymphoma who developed refractory Cryptosporidium spp. diarrhea in the setting of persistent CD4+ cytopenia. Despite receiving multiple antiparasitic agents, including failure of a prolonged course of nitazoxanide, the patient experienced persistent symptoms for 9 months with repeatedly positivity stool Cryptosporidium spp. direct fluorescent antibody (DFA) test. We highlight this case of refractory Cryptosporidium spp. and the importance of recognizing the pathogen in a non-HIV-infected immunosuppressed host.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoterapia Adotiva
/
Linfoma de Células B
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Criptosporidiose
Tipo de estudo:
Etiology_studies
Limite:
Aged80
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Female
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article