Adeno-Associated Virus Vector Gene Delivery Elevates Factor I Levels and Downregulates the Complement Alternative Pathway <i>In Vivo</i>.

Ahmad, Amina; Mandwie, Mawj; Dreismann, Anna K; Smyth, Christine M; Doyle, Helen; Malik, Talat H; Pickering, Matthew C; Lachmann, Peter J; Alexander, Ian E; Logan, Grant J

Adeno-Associated Virus Vector Gene Delivery Elevates Factor I Levels and Downregulates the Complement Alternative Pathway In Vivo.

Ahmad, Amina; Mandwie, Mawj; Dreismann, Anna K; Smyth, Christine M; Doyle, Helen; Malik, Talat H; Pickering, Matthew C; Lachmann, Peter J; Alexander, Ian E; Logan, Grant J.

Afiliação

Ahmad A; Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, University of Sydney, Westmead, Australia.
Mandwie M; Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, University of Sydney, Westmead, Australia.
Dreismann AK; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Smyth CM; Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, University of Sydney, Westmead, Australia.
Doyle H; Pathology, Sydney Children's Hospitals Network, Westmead, Australia.
Malik TH; Centre for Inflammatory Disease, Imperial College London, United Kingdom; and.
Pickering MC; Centre for Inflammatory Disease, Imperial College London, United Kingdom; and.
Lachmann PJ; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Alexander IE; Gene Therapy Research Unit, Children's Medical Research Institute and Sydney Children's Hospitals Network, University of Sydney, Westmead, Australia.
Logan GJ; Discipline of Child and Adolescent Health, University of Sydney, Westmead, Australia.

Hum Gene Ther ; 32(21-22): 1370-1381, 2021 11.

Article em En | MEDLINE | ID: mdl-34238030

Assuntos

Dependovirus; Fibrinogênio; Animais; Ativação do Complemento/genética; Proteínas do Sistema Complemento/genética; Dependovirus/genética; Camundongos

Palavras-chave

adeno-associated virus; alternative pathway; complement; factor I; immune modulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrinogênio / Dependovirus Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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