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Non-viral approaches for somatic cell reprogramming into cardiomyocytes.
Zhou, Wei; Ma, Tianhua; Ding, Sheng.
Afiliação
  • Zhou W; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
  • Ma T; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
  • Ding S; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: sheng.ding@mail.tsinghua.edu.cn.
Semin Cell Dev Biol ; 122: 28-36, 2022 02.
Article em En | MEDLINE | ID: mdl-34238675
Heart disease is the leading cause of human deaths worldwide. Due to lacking cardiomyocytes with replicative capacity and cardiac progenitor cells with differentiation potential in adult hearts, massive loss of cardiomyocytes after ischemic events produces permanent damage, ultimately leading to heart failure. Cellular reprogramming is a promising strategy to regenerate heart by induction of cardiomyocytes from other cell types, such as cardiac fibroblasts. In contrast to conventional virus-based cardiac reprogramming, non-viral approaches greatly reduce the potential risk that includes disruption of genome integrity by integration of foreign DNAs, expression of exogenous genes with oncogenic potential, and appearance of partially reprogrammed cells harmful for the physiological functions of tissues/organs, which impedes their in-vivo applications. Here, we review the recent progress in development of non-viral approaches to directly reprogram somatic cells towards cardiomyocytes and their therapeutic application for heart regeneration.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miócitos Cardíacos / Medicina Regenerativa / Reprogramação Celular Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miócitos Cardíacos / Medicina Regenerativa / Reprogramação Celular Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article