Protective effect of rapamycin in models of retinal degeneration.
Exp Eye Res
; 210: 108700, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-34245755
ABSTRACT
Age-related macular degeneration (AMD) is a complex retinal disease with no viable treatment strategy. The causative mechanistic pathway for this disease is not yet clear. Therefore, it is highly warranted to screen effective drugs to treat AMD. Rapamycin are known to inhibit inflammation and has been widely used in the clinic as an immunosuppressant. This study aimed to investigate the protective effect of rapamycin on the AMD retinal degeneration model. The AMD models were established by injection of 35 mg/kg sodium iodate (NaIO3) into the tail vein. Then the treated mice intraperitoneally received rapamycin (2 mg/kg) once a day. The histomorphological analysis showed that rapamycin could inhibit retinal structure damage and apoptosis. Experiments revealed that rapamycin significantly attenuated inflammatory response and oxidative stress. Our experimental results demonstrated that rapamycin has protected the retinal against degeneration induced by NaIO3. The therapeutic effect was more significant after 7 days of treatment. Therefore, our study potentially provides a powerful experimental support for the treatment of AMD.
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Base de dados:
MEDLINE
Assunto principal:
Degeneração Retiniana
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Sirolimo
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Modelos Animais de Doenças
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Epitélio Pigmentado da Retina
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Imunossupressores
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article