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Inhibition of MEK5/ERK5 signaling overcomes acquired resistance to the third generation EGFR inhibitor, osimertinib, via enhancing Bim-dependent apoptosis.
Zhao, Wen; Yu, Danlei; Chen, Zhen; Yao, Weilong; Yang, Jin; Ramalingam, Suresh S; Sun, Shi-Yong.
Afiliação
  • Zhao W; Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
  • Yu D; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
  • Chen Z; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
  • Yao W; Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
  • Yang J; Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
  • Ramalingam SS; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
  • Sun SY; Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA. Electronic address: ssun@emory.edu.
Cancer Lett ; 519: 141-149, 2021 10 28.
Article em En | MEDLINE | ID: mdl-34245854
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acrilamidas / Apoptose / Carcinoma Pulmonar de Células não Pequenas / MAP Quinase Quinase 5 / Proteína Quinase 7 Ativada por Mitógeno / Inibidores de Proteínas Quinases / Proteína 11 Semelhante a Bcl-2 / Compostos de Anilina / Neoplasias Pulmonares Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acrilamidas / Apoptose / Carcinoma Pulmonar de Células não Pequenas / MAP Quinase Quinase 5 / Proteína Quinase 7 Ativada por Mitógeno / Inibidores de Proteínas Quinases / Proteína 11 Semelhante a Bcl-2 / Compostos de Anilina / Neoplasias Pulmonares Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article