The biological function of IGF2BPs and their role in tumorigenesis.
Invest New Drugs
; 39(6): 1682-1693, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34251559
ABSTRACT
The insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) pertain to a highly conservative RNA-binding family that works as a post-transcriptional fine-tuner for target transcripts. Emerging evidence suggests that IGF2BPs regulate RNA processing and metabolism, including stability, translation, and localization, and are involved in various cellular functions and pathophysiologies. In this review, we summarize the roles and molecular mechanisms of IGF2BPs in cancer development and progression. We mainly discuss the functional relevance of IGF2BPs in embryo development, neurogenesis, metabolism, RNA processing, and tumorigenesis. Understanding IGF2BPs role in tumor progression will provide new insight into cancer pathophysiology.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like II
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Proteínas de Ligação a RNA
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Carcinogênese
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article