Your browser doesn't support javascript.
loading
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.
Kohnke, Sara; Buller, Sophie; Nuzzaci, Danae; Ridley, Katherine; Lam, Brian; Pivonkova, Helena; Bentsen, Marie A; Alonge, Kimberly M; Zhao, Chao; Tadross, John; Holmqvist, Staffan; Shimizu, Takahiro; Hathaway, Hannah; Li, Huiliang; Macklin, Wendy; Schwartz, Michael W; Richardson, William D; Yeo, Giles S H; Franklin, Robin J M; Karadottir, Ragnhildur T; Rowitch, David H; Blouet, Clemence.
Afiliação
  • Kohnke S; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Buller S; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Nuzzaci D; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Ridley K; Department of Paediatrics and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Lam B; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Pivonkova H; Wellcome-MRC Cambridge Stem Cell Institute, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
  • Bentsen MA; University of Washington Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Alonge KM; University of Washington Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Zhao C; Wellcome-MRC Cambridge Stem Cell Institute, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Tadross J; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Holmqvist S; Department of Paediatrics and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Shimizu T; Wolfson Institute for Biomedical Research, University College London, London, UK.
  • Hathaway H; Department of Cell & Developmental Biology and Program in Neuroscience, University of Colorado School of Medicine, Aurora, CO, USA.
  • Li H; Wolfson Institute for Biomedical Research, University College London, London, UK.
  • Macklin W; Department of Cell & Developmental Biology and Program in Neuroscience, University of Colorado School of Medicine, Aurora, CO, USA.
  • Schwartz MW; University of Washington Medicine Diabetes Institute, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Richardson WD; Wolfson Institute for Biomedical Research, University College London, London, UK.
  • Yeo GSH; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Franklin RJM; Wellcome-MRC Cambridge Stem Cell Institute, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Karadottir RT; Wellcome-MRC Cambridge Stem Cell Institute, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
  • Rowitch DH; Department of Paediatrics and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Wolfson Institute for Biomedical Research, University College London, London, UK.
  • Blouet C; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: csb69@medschl.cam.ac.uk.
Cell Rep ; 36(2): 109362, 2021 07 13.
Article em En | MEDLINE | ID: mdl-34260928
The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy balance. Here, we show that refeeding after an overnight fast rapidly triggers proliferation and differentiation of oligodendrocyte progenitors, leading to the production of new oligodendrocytes in the ME specifically. During this nutritional paradigm, ME perineuronal nets (PNNs), emerging regulators of ARH metabolic functions, are rapidly remodeled, and this process requires myelin regulatory factor (Myrf) in oligodendrocyte progenitors. In genetically obese ob/ob mice, nutritional regulations of ME oligodendrocyte differentiation and PNN remodeling are blunted, and enzymatic digestion of local PNN increases food intake and weight gain. We conclude that MBH PNNs are required for the maintenance of energy balance in lean mice and are remodeled in the adult ME by the nutritional control of oligodendrocyte differentiation.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Oligodendroglia / Eminência Mediana / Rede Nervosa / Fenômenos Fisiológicos da Nutrição Limite: Adult / Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Oligodendroglia / Eminência Mediana / Rede Nervosa / Fenômenos Fisiológicos da Nutrição Limite: Adult / Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article