Emerging non-pharmacological interventions in ADPKD: an update on dietary advices for clinical practice.
Curr Opin Nephrol Hypertens
; 30(5): 482-492, 2021 09 01.
Article
em En
| MEDLINE
| ID: mdl-34261861
ABSTRACT
PURPOSE OF REVIEW Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) reach kidney failure at a median age of 58âyears. There has been a strong interest in medical interventions to improve prognosis. With increasing understanding of the underlying pathophysiology, there is also a rationale for non-pharmaceutical interventions. However, these have received little attention. This review, therefore, focuses on dietary interventions in ADPKD. RECENT FINDINGS:
Recent studies regarding salt, protein and water intake, caloric restriction, BMI, caffeine and alcohol are discussed in this review. In general, these studies suggest that advices do not need to be different from those in chronic kidney disease (CKD). On the basis of research in the general population and CKD, these advices will likely decrease cardiovascular morbidity and mortality. With respect to delaying ADPKD progression, evidence for salt restriction is growing. For increasing water intake and targeting glucose metabolism by intermittent fasting, preclinical studies are promising. Long-term randomized human intervention studies are, however, lacking.SUMMARY:
In ADPKD, advices regarding dietary interventions can, in general, be the same as in CKD to decrease cardiovascular morbidity and mortality. Whether these interventions also delay disease progression needs further study.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rim Policístico Autossômico Dominante
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Insuficiência Renal Crônica
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Humans
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article