Targeting LIN28: a new hope in prostate cancer theranostics.
Future Oncol
; 17(29): 3873-3880, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34263659
ABSTRACT
The mortality and morbidity rates for prostate cancer have recently increased to alarming levels, rising higher than lung cancer. Due to a lack of drug targets and molecular probes, existing theranostic techniques are limited. Human LIN28A and its paralog LIN28B overexpression are associated with a number of tumors resulting in a remarkable increase in cancer aggression and poor prognoses. The current review aims to highlight recent work identifying the key roles of LIN28A and LIN28B in prostate cancer, and to instigate further preclinical and clinical research in this important area.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Proteínas de Ligação a RNA
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Medicina de Precisão
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Terapia de Alvo Molecular
Limite:
Humans
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article