The efficacy of Î³-aminobutyric acid type A receptor (GABA <sub>A</sub>R) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation.

Mundy, Paige C; Pressly, Brandon; Carty, Dennis R; Yaghoobi, Bianca; Wulff, Heike; Lein, Pamela J

The efficacy of Î³-aminobutyric acid type A receptor (GABA _AR) subtype-selective positive allosteric modulators in blocking tetramethylenedisulfotetramine (TETS)-induced seizure-like behavior in larval zebrafish with minimal sedation.

Mundy, Paige C; Pressly, Brandon; Carty, Dennis R; Yaghoobi, Bianca; Wulff, Heike; Lein, Pamela J.

Afiliação

Mundy PC; Department of Molecular Biosciences, University of California, School of Veterinary Medicine, Davis, CA 95616, United States. Electronic address: pacmundy@ucdavis.edu.
Pressly B; Department of Pharmacology, University of California, School of Medicine, Davis, CA 95616, United States. Electronic address: bpressly@ucdavis.edu.
Carty DR; Department of Molecular Biosciences, University of California, School of Veterinary Medicine, Davis, CA 95616, United States.
Yaghoobi B; Department of Molecular Biosciences, University of California, School of Veterinary Medicine, Davis, CA 95616, United States. Electronic address: byaghoobi@ucdavis.edu.
Wulff H; Department of Pharmacology, University of California, School of Medicine, Davis, CA 95616, United States. Electronic address: hwulff@ucdavis.edu.
Lein PJ; Department of Molecular Biosciences, University of California, School of Veterinary Medicine, Davis, CA 95616, United States. Electronic address: pjlein@ucdavis.edu.

Toxicol Appl Pharmacol ; 426: 115643, 2021 09 01.

Article em En | MEDLINE | ID: mdl-34265354

Assuntos

Hidrocarbonetos Aromáticos com Pontes; Convulsivantes; Moduladores GABAérgicos/farmacologia; Hipnóticos e Sedativos/farmacologia; Subunidades Proteicas/fisiologia; Receptores de GABA-A/fisiologia; Convulsões/induzido quimicamente; Animais; Comportamento Animal/efeitos dos fármacos; Larva; Locomoção/efeitos dos fármacos; Midazolam/farmacologia; Subunidades Proteicas/genética; Receptores de GABA-A/genética; Convulsões/fisiopatologia; Peixe-Zebra

Palavras-chave

Benzodiazepine; Chemical Threat Agent; GABA(A)R; Seizures; Tetramethylenedisulfotetramine; Zebrafish

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Convulsões / Hidrocarbonetos Aromáticos com Pontes / Receptores de GABA-A / Moduladores GABAérgicos / Convulsivantes / Subunidades Proteicas / Hipnóticos e Sedativos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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