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Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions.
Valdebenito, Silvana; Malik, Shaily; Luu, Ross; Loudig, Olivier; Mitchell, Megan; Okafo, George; Bhat, Krishna; Prideaux, Brendan; Eugenin, Eliseo A.
Afiliação
  • Valdebenito S; Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB), Research Building 17, Fifth Floor, 105 11th Street, Galveston, TX, 77555, USA.
  • Malik S; Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB), Research Building 17, Fifth Floor, 105 11th Street, Galveston, TX, 77555, USA.
  • Luu R; Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB), Research Building 17, Fifth Floor, 105 11th Street, Galveston, TX, 77555, USA.
  • Loudig O; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
  • Mitchell M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
  • Okafo G; GO Pharma-Consulting Ltd., Welwyn, UK.
  • Bhat K; Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, M.D. Anderson, Houston, TX, USA.
  • Prideaux B; Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB), Research Building 17, Fifth Floor, 105 11th Street, Galveston, TX, 77555, USA.
  • Eugenin EA; Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB), Research Building 17, Fifth Floor, 105 11th Street, Galveston, TX, 77555, USA. eleugeni@UTMB.edu.
Sci Rep ; 11(1): 14556, 2021 07 15.
Article em En | MEDLINE | ID: mdl-34267246
Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, function, and contribution of TNT to cancer pathogenesis are poorly understood. Our analyses demonstrate that TNT structures are induced between glioblastoma (GBM) cells and surrounding non-tumor astrocytes to transfer tumor-derived mitochondria. The mitochondrial transfer mediated by TNT resulted in the adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions. In conclusion, TNT are an efficient cell-to-cell communication system used by cancer cells to adapt the microenvironment to the invasive nature of the tumor.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Astrócitos / Glioblastoma / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Astrócitos / Glioblastoma / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article