Mutasynthesis of Antibacterial Halogenated Actinomycin Analogues.
J Nat Prod
; 84(8): 2217-2225, 2021 08 27.
Article
em En
| MEDLINE
| ID: mdl-34270246
ABSTRACT
Through precursor-directed biosynthesis, feeding halogenated (F-, Cl-, Br-, I-) or methoxy-substituted 4-methyl-3-hydroxyanthranilic acid (4-MHA) analogues to the acnGHLM-deleted mutant strain of Streptomyces costaricanus SCSIO ZS0073 led to the production of ten new actinomycin analogues (4-13). Several of the actinomycin congeners displayed impressive antimicrobial activities, with MIC values spanning 0.06-64 µg/mL to clinically derived antibiotic resistant pathogens, including Staphylococcus aureus, Enterococcus faecium, and Candida albicans, with low cytotoxicity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Dactinomicina
/
Anti-Infecciosos
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article