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Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.
Hinterdobler, Julia; Schott, Simin; Jin, Hong; Meesmann, Almut; Steinsiek, Anna-Lena; Zimmermann, Anna-Sophia; Wobst, Jana; Müller, Philipp; Mauersberger, Carina; Vilne, Baiba; Baecklund, Alexandra; Chen, Chien-Sin; Moggio, Aldo; Braster, Quinte; Molitor, Michael; Krane, Markus; Kempf, Wolfgang E; Ladwig, Karl-Heinz; Hristov, Michael; Hulsmans, Maarten; Hilgendorf, Ingo; Weber, Christian; Wenzel, Philip; Scheiermann, Christoph; Maegdefessel, Lars; Soehnlein, Oliver; Libby, Peter; Nahrendorf, Matthias; Schunkert, Heribert; Kessler, Thorsten; Sager, Hendrik B.
Afiliação
  • Hinterdobler J; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Schott S; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Jin H; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Meesmann A; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Steinsiek AL; Department of Medicine, Karolinska Institute, Stockholm, Sweden.
  • Zimmermann AS; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Wobst J; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Müller P; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Mauersberger C; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Vilne B; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Baecklund A; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Chen CS; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Moggio A; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Braster Q; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Molitor M; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Krane M; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Kempf WE; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Ladwig KH; Bioinformatics Unit, Riga Stradins University, Riga, Latvia.
  • Hristov M; SIA net-OMICS, Riga, Latvia.
  • Hulsmans M; Department of Medicine, Karolinska Institute, Stockholm, Sweden.
  • Hilgendorf I; Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University Munich, BioMedical Centre, Planegg-Martinsried, Germany.
  • Weber C; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Wenzel P; Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilians University Munich, Munich, Germany.
  • Scheiermann C; Center for Thrombosis and Hemostasis and Department of Cardiology, University Medical Center, Mainz, Germany.
  • Maegdefessel L; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany.
  • Soehnlein O; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Libby P; Department of Cardiac Surgery, German Heart Centre Munich, Technical University Munich, Munich, Germany.
  • Nahrendorf M; Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
  • Schunkert H; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
  • Kessler T; Institute of Epidemiology Mental Health Research Unit, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Munich, Germany.
  • Sager HB; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Eur Heart J ; 42(39): 4077-4088, 2021 10 14.
Article em En | MEDLINE | ID: mdl-34279021
AIMS: Mental stress substantially contributes to the initiation and progression of human disease, including cardiovascular conditions. We aim to investigate the underlying mechanisms of these contributions since they remain largely unclear. METHODS AND RESULTS: Here, we show in humans and mice that leucocytes deplete rapidly from the blood after a single episode of acute mental stress. Using cell-tracking experiments in animal models of acute mental stress, we found that stress exposure leads to prompt uptake of inflammatory leucocytes from the blood to distinct tissues including heart, lung, skin, and, if present, atherosclerotic plaques. Mechanistically, we found that acute stress enhances leucocyte influx into mouse atherosclerotic plaques by modulating endothelial cells. Specifically, acute stress increases adhesion molecule expression and chemokine release through locally derived norepinephrine. Either chemical or surgical disruption of norepinephrine signalling diminished stress-induced leucocyte migration into mouse atherosclerotic plaques. CONCLUSION: Our data show that acute mental stress rapidly amplifies inflammatory leucocyte expansion inside mouse atherosclerotic lesions and promotes plaque vulnerability.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article