Trifluoromethyl-substituted 3,5-bis(arylidene)-4-piperidones as potential anti-hepatoma and anti-inflammation agents by inhibiting NF-ÐºB activation.

Cong, Wei; Sun, Yue; Sun, Yi-Fan; Yan, Wei-Bin; Zhang, Yu-Long; Gao, Zhong-Fei; Wang, Chun-Hua; Hou, Gui-Ge; Zhang, Jia-Jing

Cong, Wei; Sun, Yue; Sun, Yi-Fan; Yan, Wei-Bin; Zhang, Yu-Long; Gao, Zhong-Fei; Wang, Chun-Hua; Hou, Gui-Ge; Zhang, Jia-Jing.

Afiliação

Cong W; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. China.
Sun Y; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. China.
Sun YF; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. China.
Yan WB; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. China.
Zhang YL; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. China.
Gao ZF; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. China.
Wang CH; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. China.
Hou GG; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. China.
Zhang JJ; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, P. R. China.

J Enzyme Inhib Med Chem ; 36(1): 1622-1631, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34284695

Assuntos

Anti-Inflamatórios não Esteroides/farmacologia; Antineoplásicos/farmacologia; Carcinoma Hepatocelular/tratamento farmacológico; Neoplasias Hepáticas/tratamento farmacológico; NF-kappa B/antagonistas & inibidores; Piperidonas/farmacologia; Anti-Inflamatórios não Esteroides/síntese química; Anti-Inflamatórios não Esteroides/química; Antineoplásicos/síntese química; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Lipopolissacarídeos/antagonistas & inibidores; Lipopolissacarídeos/farmacologia; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Simulação de Acoplamento Molecular; Estrutura Molecular; NF-kappa B/metabolismo; Fosforilação/efeitos dos fármacos; Piperidonas/síntese química; Piperidonas/química; Relação Estrutura-Atividade

Palavras-chave

3,5-Bis(arylidene)-4-piperidones; NF-κB inhibitor; anti-hepatoma; anti-inflammation; trifluoromethyl

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidonas / Anti-Inflamatórios não Esteroides / NF-kappa B / Carcinoma Hepatocelular / Neoplasias Hepáticas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google