Rivaroxaban attenuates cardiac hypertrophy by inhibiting protease-activated receptor-2 signaling in renin-overexpressing hypertensive mice.

Narita, Masato; Hanada, Kenji; Kawamura, Yosuke; Ichikawa, Hiroaki; Sakai, Shuntaro; Yokono, Yoshikazu; Senoo, Maiko; Narita, Noritomo; Shimada, Michiko; Osanai, Tomohiro; Okumura, Ken; Tomita, Hirofumi

Narita, Masato; Hanada, Kenji; Kawamura, Yosuke; Ichikawa, Hiroaki; Sakai, Shuntaro; Yokono, Yoshikazu; Senoo, Maiko; Narita, Noritomo; Shimada, Michiko; Osanai, Tomohiro; Okumura, Ken; Tomita, Hirofumi.

Afiliação

Narita M; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Hanada K; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Kawamura Y; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Ichikawa H; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Sakai S; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Yokono Y; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Senoo M; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Narita N; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Shimada M; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Osanai T; Department of Health Promotion, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan.
Okumura K; Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan.
Tomita H; Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. tomitah@hirosaki-u.ac.jp.

Hypertens Res ; 44(10): 1261-1273, 2021 10.

Article em En | MEDLINE | ID: mdl-34285375

Assuntos

Renina; Rivaroxabana; Animais; Cardiomegalia/patologia; Inibidores do Fator Xa/farmacologia; Inibidores do Fator Xa/uso terapêutico; Fibrose; Masculino; Camundongos; Miocárdio/patologia; Receptor PAR-2; Renina/genética; Rivaroxabana/farmacologia; Rivaroxabana/uso terapêutico

Palavras-chave

Cardiac fibrosis;; Cardiac hypertrophy;; Factor Xa;; Protease-activated receptor; Rivaroxaban;

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Renina / Rivaroxabana Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Renina / Rivaroxabana Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article