Hypoxia-Overcoming Breast-Conserving Treatment by Magnetothermodynamic Implant for a Localized Free-Radical Burst Combined with Hyperthermia.
ACS Appl Mater Interfaces
; 13(30): 35484-35493, 2021 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-34289686
ABSTRACT
For the purpose of improving the quality of life and minimizing the psychological morbidity of a mastectomy, breast-conserving treatment (BCT) has become the more preferable choice in breast cancer patients. Meanwhile, tumor hypoxia has been increasingly recognized as a major deleterious factor in cancer therapies. In the current study, a novel, effective, and noninvasive magnetothermodynamic strategy based on an oxygen-independent free-radical burst for hypoxia-overcoming BCT is proposed. Radical precursor (AIPH) and iron oxide nanoparticles (IONPs) are coincorporated within the alginate (ALG) hydrogel, which is formed in situ within the tumor tissue by leveraging the cross-linking effect induced by the local physiological Ca2+ with ALG solution. Inductive heating is mediated by IONPs under AMF exposure, and consequently, regardless of the tumor hypoxia condition, a local free-radical burst is achieved by thermal decomposition of AIPH via AMF responsivity. The combination of magnetic hyperthermia and oxygen-irrelevant free-radical production effectively enhances the in vitro cytotoxic effect and also remarkably inhibits tumor proliferation. This study provides a valuable protocol for an hypoxia-overcoming strategy and also an alternative formulation candidate for noninvasive BCT.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Azo
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Neoplasias da Mama
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Espécies Reativas de Oxigênio
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Hidrogéis
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Nanopartículas Magnéticas de Óxido de Ferro
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Imidazóis
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Antineoplásicos
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article