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The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Murithi, James M; Pascal, Cécile; Bath, Jade; Boulenc, Xavier; Gnädig, Nina F; Pasaje, Charisse Flerida A; Rubiano, Kelly; Yeo, Tomas; Mok, Sachel; Klieber, Sylvie; Desert, Paul; Jiménez-Díaz, María Belén; Marfurt, Jutta; Rouillier, Mélanie; Cherkaoui-Rbati, Mohammed H; Gobeau, Nathalie; Wittlin, Sergio; Uhlemann, Anne-Catrin; Price, Ric N; Wirjanata, Grennady; Noviyanti, Rintis; Tumwebaze, Patrick; Cooper, Roland A; Rosenthal, Philip J; Sanz, Laura M; Gamo, Francisco Javier; Joseph, Jayan; Singh, Shivendra; Bashyam, Sridevi; Augereau, Jean Michel; Giraud, Elie; Bozec, Tanguy; Vermat, Thierry; Tuffal, Gilles; Guillon, Jean-Michel; Menegotto, Jérôme; Sallé, Laurent; Louit, Guillaume; Cabanis, Marie-José; Nicolas, Marie Françoise; Doubovetzky, Michel; Merino, Rita; Bessila, Nadir; Angulo-Barturen, Iñigo; Baud, Delphine; Bebrevska, Lidiya; Escudié, Fanny; Niles, Jacquin C; Blasco, Benjamin; Campbell, Simon.
Afiliação
  • Murithi JM; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  • Pascal C; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Bath J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  • Boulenc X; Sanofi Pasteur, Marcy L'Etoile, France.
  • Gnädig NF; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  • Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Rubiano K; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  • Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  • Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
  • Klieber S; Sanofi R&D, Translational Medicine & Early Development, Montpellier, France.
  • Desert P; Sanofi Pasteur, Marcy L'Etoile, France.
  • Jiménez-Díaz MB; The Art of Discovery, Bizkaia, Basque Country, Spain.
  • Marfurt J; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
  • Rouillier M; Medicines for Malaria Venture, Geneva, Switzerland.
  • Cherkaoui-Rbati MH; Medicines for Malaria Venture, Geneva, Switzerland.
  • Gobeau N; Medicines for Malaria Venture, Geneva, Switzerland.
  • Wittlin S; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Uhlemann AC; Universität Basel, Basel, Switzerland.
  • Price RN; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
  • Wirjanata G; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
  • Noviyanti R; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Tumwebaze P; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Cooper RA; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
  • Rosenthal PJ; Eijkman Institute for Molecular Biology, Jakarta, Indonesia.
  • Sanz LM; Infectious Diseases Research Collaboration, Kampala, Uganda.
  • Gamo FJ; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USA.
  • Joseph J; Department of Medicine, University of California, San Francisco, CA, USA.
  • Singh S; Global Health Pharma Research Unit, GSK, Tres Cantos, Madrid, Spain.
  • Bashyam S; Global Health Pharma Research Unit, GSK, Tres Cantos, Madrid, Spain.
  • Augereau JM; Syngene International Ltd., Bangalore, India.
  • Giraud E; Syngene International Ltd., Bangalore, India.
  • Bozec T; Syngene International Ltd., Bangalore, India.
  • Vermat T; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Tuffal G; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Guillon JM; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Menegotto J; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Sallé L; Sanofi R&D, Translational Medicine & Early Development, Montpellier, France.
  • Louit G; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Cabanis MJ; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Nicolas MF; Sanofi R&D, Translational Medicine & Early Development, Montpellier, France.
  • Doubovetzky M; Sanofi, Vitry-sur-Seine, France.
  • Merino R; Sanofi R&D, Translational Medicine & Early Development, Montpellier, France.
  • Bessila N; Sanofi, Vitry-sur-Seine, France.
  • Angulo-Barturen I; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Baud D; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Bebrevska L; Sanofi, Infectious Diseases Therapeutic Area, Marcy l'Etoile, France.
  • Escudié F; The Art of Discovery, Bizkaia, Basque Country, Spain.
  • Niles JC; Medicines for Malaria Venture, Geneva, Switzerland.
  • Blasco B; Medicines for Malaria Venture, Geneva, Switzerland.
  • Campbell S; Medicines for Malaria Venture, Geneva, Switzerland.
Sci Transl Med ; 13(603)2021 07 21.
Article em En | MEDLINE | ID: mdl-34290058
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Parasitos / Malária Falciparum / Malária / Antimaláricos Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Parasitos / Malária Falciparum / Malária / Antimaláricos Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article