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Fatigue is associated with depression independent of excessive daytime sleepiness in the general population.
Sunwoo, Jun-Sang; Kim, Daeyoung; Chu, Min Kyung; Yun, Chang-Ho; Yang, Kwang Ik.
Afiliação
  • Sunwoo JS; Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea.
  • Kim D; Department of Neurology, Chungnam National University College of Medicine, Chungnam National University Hospital, Daejeon, South Korea.
  • Chu MK; Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Yun CH; Department of Neurology, Bundang Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
  • Yang KI; Sleep Disorders Center, Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan, 31151, South Korea. neurofan@schmc.ac.kr.
Sleep Breath ; 26(2): 933-940, 2022 06.
Article em En | MEDLINE | ID: mdl-34292460
PURPOSE: This study aimed to investigate sleep problems and comorbid conditions associated with fatigue in the general population. METHODS: The data were obtained from a nationwide cross-sectional survey conducted in 2018. The Fatigue Severity Scale was used to assess fatigue. We examined sleep habits, such as workday sleep duration, chronotype, and free-day catch-up sleep, excessive daytime sleepiness (EDS), depression, and other comorbid conditions. We conducted multiple logistic regression analysis with the presence of fatigue as a dependent variable. RESULTS: Of 2,493 adults aged 19 to 92 years, 50% men, mean age was 47.9 ± 16.4 years. The average workday sleep duration was 7.1 ± 1.1 h, and the prevalence of fatigue was 31%. After adjusting for potential confounders, fatigue was associated with EDS (odds ratio [OR] 3.751, 95% confidence interval [CI] 2.928-4.805), depression (OR 3.736, 95% CI 2.701-5.169), perceived insufficient sleep (OR 1.516, 95% CI 1.249-1.839), free-day catch-up sleep (OR 1.123, 95% CI 1.020-1.235), less alcohol intake (OR 0.570, 95% CI 0.432-0.752), and physical inactivity (OR 0.737, 95% CI 0.573-0.948). On subgroup analysis, fatigue was additionally associated with short workday sleep duration (OR 0.899, 95% CI 0.810-0.997) in individuals without EDS. However, among those with EDS, only depression (OR 2.842, 95% CI 1.511-5.343) and less alcohol intake (OR 0.476, 95% CI 0.247-0.915) were associated with fatigue. CONCLUSION: Fatigue was significantly associated with depression independent of EDS. Further research is warranted to better understand the pathophysiological relationship between fatigue, depression, and sleep.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos do Sono-Vigília / Distúrbios do Sono por Sonolência Excessiva Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos do Sono-Vigília / Distúrbios do Sono por Sonolência Excessiva Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article