Fibroblasts: Origins, definitions, and functions in health and disease.
Cell
; 184(15): 3852-3872, 2021 07 22.
Article
em En
| MEDLINE
| ID: mdl-34297930
ABSTRACT
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and disease by producing complex extracellular matrix and creating signaling niches through biophysical and biochemical cues. Transcriptionally and functionally heterogeneous across and within organs, fibroblasts encode regional positional information and maintain distinct cellular progeny. We summarize their development, lineages, functions, and contributions to fibrosis in four fibroblast-rich organs skin, lung, skeletal muscle, and heart. We propose that fibroblasts are uniquely poised for tissue repair by easily reentering the cell cycle and exhibiting a reversible plasticity in phenotype and cell fate. These properties, when activated aberrantly, drive fibrotic disorders in humans.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Saúde
/
Doença
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Fibroblastos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article