Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry.
Int J Mol Sci
; 22(14)2021 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-34299029
ABSTRACT
Curcumin is a natural occurring molecule that has aroused much interest among researchers over the years due to its pleiotropic set of biological properties. In the nuclear medicine field, radiolabelled curcumin and curcumin derivatives have been studied as potential radiotracers for the early diagnosis of Alzheimer's disease and cancer. In the present review, the synthetic pathways, labelling methods and the preclinical investigations involving these radioactive compounds are treated. The studies entailed chemical modifications for enhancing curcumin stability, as well as its functionalisation for the labelling with several radiohalogens or metal radionuclides (fluorine-18, technetium-99m, gallium-68, etc.). Although some drawbacks have yet to be addressed, and none of the radiolabelled curcuminoids have so far achieved clinical application, the studies performed hitherto provide useful insights and lay the foundation for further developments.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Química Farmacêutica
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Compostos Radiofarmacêuticos
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Curcumina
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Antineoplásicos
Tipo de estudo:
Screening_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article