6-Gingerol, a Major Constituent of <i>Zingiber officinale</i> Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish.

Gawel, Kinga; Kukula-Koch, Wirginia; Banono, Nancy Saana; Nieoczym, Dorota; Targowska-Duda, Katarzyna M; Czernicka, Lidia; Parada-Turska, Jolanta; Esguerra, Camila V

6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish.

Gawel, Kinga; Kukula-Koch, Wirginia; Banono, Nancy Saana; Nieoczym, Dorota; Targowska-Duda, Katarzyna M; Czernicka, Lidia; Parada-Turska, Jolanta; Esguerra, Camila V.

Afiliação

Gawel K; Chemical Neuroscience Group, Centre for Molecular Medicine Norway, Faculty of Medicine, University of Oslo, Gaustadalléen 21, 0349 Oslo, Norway.
Kukula-Koch W; Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego Str. 8b, 20-090 Lublin, Poland.
Banono NS; Chair and Department of Pharmacognosy, Medical University of Lublin, Chodzki Str. 1, 20-093 Lublin, Poland.
Nieoczym D; Chemical Neuroscience Group, Centre for Molecular Medicine Norway, Faculty of Medicine, University of Oslo, Gaustadalléen 21, 0349 Oslo, Norway.
Targowska-Duda KM; Department of Animal Physiology and Pharmacology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Marie Curie-Sklodowska University, Akademicka Str. 19, 20-033 Lublin, Poland.
Czernicka L; Department of Biopharmacy, Medical University of Lublin, Chodzki Str. 4a, 20-093 Lublin, Poland.
Parada-Turska J; Chair and Department of Food and Nutrition, Medical University of Lublin, Chodzki Str. 4a, 20-093 Lublin, Poland.
Esguerra CV; Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, 20-090 Lublin, Poland.

Int J Mol Sci ; 22(14)2021 Jul 20.

Article em En | MEDLINE | ID: mdl-34299361

Assuntos

Anticonvulsivantes/farmacologia; Catecóis/farmacologia; Álcoois Graxos/farmacologia; Pentilenotetrazol/farmacologia; Extratos Vegetais/farmacologia; Convulsões/induzido quimicamente; Convulsões/tratamento farmacológico; Zingiber officinale/química; Animais; Encéfalo/efeitos dos fármacos; Encéfalo/metabolismo; Epilepsia/tratamento farmacológico; Epilepsia/metabolismo; Larva/efeitos dos fármacos; Larva/metabolismo; Receptores de N-Metil-D-Aspartato/metabolismo; Convulsões/metabolismo; Peixe-Zebra; Ácido gama-Aminobutírico/metabolismo

Palavras-chave

6-gingerol; EEG; Zingiber officinale; anticonvulsant activity; isolation; molecular docking; neurotransmitter profiling; pentylenetetrazole; seizures; zebrafish

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pentilenotetrazol / Convulsões / Extratos Vegetais / Catecóis / Zingiber officinale / Álcoois Graxos / Anticonvulsivantes Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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