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Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature.
Koelsche, Christian; Benhamida, Jamal K; Kommoss, Felix K F; Stichel, Damian; Jones, David T W; Pfister, Stefan M; Heilig, Christoph E; Fröhling, Stefan; Stenzinger, Albrecht; Buslei, Rolf; Mentzel, Thomas; Baumhoer, Daniel; Ladanyi, Marc; Antonescu, Cristina R; Flucke, Uta; Gorp, Joost van; Bode-Lesniewska, Beata; Deimling, Andreas von; Mechtersheimer, Gunhild.
Afiliação
  • Koelsche C; Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. Christian.Koelsche@med.uni-heidelberg.de.
  • Benhamida JK; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
  • Kommoss FKF; Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Stichel D; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Jones DTW; Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Heilig CE; Paediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Fröhling S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
  • Stenzinger A; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Buslei R; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
  • Mentzel T; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Baumhoer D; Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Ladanyi M; Department of General Pathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Antonescu CR; Institute of Pathology, Sozialstiftung Bamberg, Bamberg, Germany.
  • Flucke U; Dermatopathology Bodensee, Friedrichshafen, Germany.
  • Gorp JV; Bone Tumor Reference Center at the Institute of Medical Genetics and Pathology, University Hospital and University of Basel, Basel, Switzerland.
  • Bode-Lesniewska B; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
  • Deimling AV; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.
  • Mechtersheimer G; Department of Pathology, Radboud University Hospital, Nijmegen, the Netherlands.
Mod Pathol ; 34(12): 2122-2129, 2021 12.
Article em En | MEDLINE | ID: mdl-34312479
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcoma / DNA de Neoplasias / Proteínas Proto-Oncogênicas / Proteínas de Ciclo Celular / Metilação de DNA / Proteínas Proto-Oncogênicas c-mdm2 / Quinase 6 Dependente de Ciclina / Neoplasias Cardíacas Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcoma / DNA de Neoplasias / Proteínas Proto-Oncogênicas / Proteínas de Ciclo Celular / Metilação de DNA / Proteínas Proto-Oncogênicas c-mdm2 / Quinase 6 Dependente de Ciclina / Neoplasias Cardíacas Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article