New antimicrobial self-assembling short lipopeptides.
Org Biomol Chem
; 19(31): 6797-6803, 2021 08 11.
Article
em En
| MEDLINE
| ID: mdl-34319330
ABSTRACT
Lipopeptides are an exceptional example of amphiphilic molecules that self-assemble into functional structures with applications in the areas of nanotechnology, catalysis or medicinal chemistry. Herein, we report a library of 21 short lipopeptides, together with their supramolecular characterization and antimicrobial activity against both Gram-negative (E. coli) and Gram-positive (S. aureus) strains. This study shows that simple lipoamino acids self-assemble into micellar or vesicular structures, while incorporating dipeptides capable of stablishing hydrogen bonds results in the adoption of advanced fibrilar structures. The self-assembly effect has proven to be key to achieve antimicrobial activity.
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1
Base de dados:
MEDLINE
Assunto principal:
Lipopeptídeos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article