SARS-CoV-2 pseudovirus infectivity and expression of viral entry-related factors ACE2, TMPRSS2, Kim-1, and NRP-1 in human cells from the respiratory, urinary, digestive, reproductive, and immune systems.

Zhang, Fei; Li, Wan; Feng, Jian; Ramos da Silva, Suzane; Ju, Enguo; Zhang, Hu; Chang, Yuan; Moore, Patrick S; Guo, Haitao; Gao, Shou-Jiang

Zhang, Fei; Li, Wan; Feng, Jian; Ramos da Silva, Suzane; Ju, Enguo; Zhang, Hu; Chang, Yuan; Moore, Patrick S; Guo, Haitao; Gao, Shou-Jiang.

Afiliação

Zhang F; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Li W; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Feng J; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ramos da Silva S; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ju E; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Zhang H; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Chang Y; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Moore PS; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Guo H; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Gao SJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

J Med Virol ; 93(12): 6671-6685, 2021 12.

Article em En | MEDLINE | ID: mdl-34324210

Assuntos

Enzima de Conversão de Angiotensina 2/metabolismo; Trato Gastrointestinal/virologia; Genitália/virologia; Receptor Celular 1 do Vírus da Hepatite A/metabolismo; Sistema Imunitário/virologia; Neuropilina-1/metabolismo; Sistema Respiratório/virologia; SARS-CoV-2/fisiologia; Serina Endopeptidases/metabolismo; Internalização do Vírus; Western Blotting; COVID-19/metabolismo; COVID-19/virologia; Linhagem Celular; Células Cultivadas; Imunofluorescência; Trato Gastrointestinal/citologia; Genitália/citologia; Humanos; Sistema Imunitário/citologia; Sistema Respiratório/citologia

Palavras-chave

Angiotensin-converting enzyme 2 (ACE2); Kim-1; NRP-1; SARS-CoV; SARS-CoV-2; TMPRSS2; and glycosylation; pseudovirus; receptor binding domain (RBD); spike protein; viral entry tropism; virus receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Respiratório / Serina Endopeptidases / Neuropilina-1 / Trato Gastrointestinal / Internalização do Vírus / Receptor Celular 1 do Vírus da Hepatite A / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / Genitália / Sistema Imunitário Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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