Strain-release C-C bond cleavage enables the [2,3]-sigmatropic rearrangement of tertiary allylamines.
Chem Commun (Camb)
; 57(68): 8449-8451, 2021 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-34342309
ABSTRACT
A new strategy has been established for the [2,3]-sigmatropic rearrangement of quaternary allylammonium ylides, generated in situ from tertiary allylamines and a bicyclo[1.1.0]butane via strain-release C-C bond cleavage. A range of tertiary allylamines with an acidic α-C-H bond participated in the 1-sulfonylbicyclo[1.1.0]butane-mediated [2,3]-sigmatropic rearrangement, delivering structurally diverse N-cyclobutyl homoallylamines in moderate to excellent yields.
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MEDLINE
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En
Ano de publicação:
2021
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Article