Reference interval and the role of plasma oligomeric beta amyloid in screening of risk groups for cognitive dysfunction at health checkups.
J Clin Lab Anal
; 35(9): e23933, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-34342379
ABSTRACT
BACKGROUND:
Alzheimer's disease (AD) has a prolonged preclinical stage characterized by cognitive dysfunction. Simple, reliable, and noninvasive biomarkers reflecting the pathogenesis of AD are needed for screening cognitive dysfunction in primary health care. The aims of this study were to determine (1) the potential utility of the Multimer Detection System-Oligomeric Amyloid-ß (MDS-OAß) value in cognitive assessments and (2) the reference interval (RI) of plasma MDS-OAß values in the general population.METHODS:
This prospective study consecutively recruited 1,594 participants who underwent health checkups including cognitive function examination at 16 health-promotion centers in Korea between December 2020 and January 2021. The inBloodTM OAß test (PeopleBio, Gyeonggi-do, Republic of Korea) was utilized to quantify MDS-OAß values in plasma. The reference subjects were obtained among those with normal general cognition on cognitive screening tools. RIs were established according to the CLSI C28-A3 guidelines.RESULTS:
The median MDS-OAß value was higher in subjects with Korean Dementia Screening Questionnaire-Cognition (KDSQ-C) scores ≥8 than in those with KDSQ-C scores of 6-7 (P = 0.013). The median MDS-OAß value was higher in subjects with Mini-Mental State Examination for Dementia Screening (MMSE-DS) scores of 21-26 than in those with MMSE-DS scores ≥27 (P = 0.011). The RI (one-side upper 95th percentile) of the MDS-OAß value was 0.80 ng/mL (95% confidence interval = 0.78-0.82) in those aged ≥50 years.CONCLUSIONS:
The plasma MDS-OAß value reflects cognitive function as assessed using the KDSQ-C and MMSE-DS. RIs obtained from a large and cognitively healthy community-based sample are presented.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Peptídeos beta-Amiloides
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Disfunção Cognitiva
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Qualitative_research
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Risk_factors_studies
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Screening_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article