Walsogynes H-O from Walsura chrysogyne.
J Nat Med
; 76(1): 94-101, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-34351584
ABSTRACT
Eight new limonoids, walsogynes H-O (1-8) were isolated from the barks of Walsura chrysogyne, and their structures were determined on the basis of the 1D and 2D NMR data. Walsogynes H-M (1-6) and O (8) were concluded to be 11,12-seco limonoids with a dodecahydro-1H-naphtho[1,8-bc3,4-c']difuran skeleton, and walsogyne N (7) to be 11,12-seco limonoid sharing a unique dodecahydronaphtho[1,8-bc5,4-b'c']difuran skeleton. Walsogynes H-O (1-8) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC50 value of 2.5, 2.6, 1.6, 2.5, 1.5, 2.6, 2.1, and 1.1 µM, respectively.
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Base de dados:
MEDLINE
Assunto principal:
Meliaceae
/
Limoninas
/
Antimaláricos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article