Systems modeling of metabolic dysregulation in neurodegenerative diseases.
Curr Opin Pharmacol
; 60: 59-65, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34352486
Neurodegenerative diseases (NDDs) encompass a wide range of conditions that arise owing to progressive degeneration and the ultimate loss of nerve cells in the brain and peripheral nervous system. NDDs such as Alzheimer's, Parkinson's, and Huntington's diseases negatively impact both length and quality of life, due to lack of effective disease-modifying treatments. Herein, we review the use of genome-scale metabolic models, network-based approaches, and integration with multiomics data to identify key biological processes that characterize NDDs. We describe powerful systems biology approaches for modeling NDD pathophysiology by leveraging in silico models that are informed by patient-derived multiomics data. These approaches can enable mechanistic insights into NDD-specific metabolic dysregulations that can be leveraged to identify potential metabolic markers of disease and predisease states.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença de Huntington
/
Doenças Neurodegenerativas
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article